Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 AxisSummary
Background & Aims: Intratumor heterogeneity is a common feature of colorectal cancer (CRC).Here, we analyzed whether mesenchymal-like CRC cells promote the progression of epithelial-like CRC cells via paracrine mechanisms.Methods: Six CRC cell lines that show an epithelial phenotype were treated with conditioned media (CM) from CRC cell lines that